This presentation provides a comprehensive overview of leprosy, encompassing its historical context, causative factors, mechanisms of disease development, and various therapeutic strategies. We will examine the evolution of understanding about leprosy, from ancient times to present-day scientific advancements. Furthermore, the report delves into the intricate molecular interactions that govern the progression of leprosy, impacting the immune response and the resulting clinical manifestations. This educational overview seeks to offer a detailed and easily understood understanding of leprosy for the target audience.