This presentation provides a comprehensive overview of malabsorption syndromes impacting the gastrointestinal tract, specifically focusing on cystic fibrosis, celiac disease, and Crohn's disease. We will delve into the pathophysiology of each condition, exploring the mechanisms leading to impaired nutrient absorption. The diagnostic approaches, including clinical assessments, laboratory tests, and imaging techniques used to identify and characterize these disorders, will be highlighted. Furthermore, we will examine the therapeutic strategies, encompassing dietary modifications, pharmacological interventions, and surgical options, aimed at managing these complex conditions and improving patient outcomes.